In 1971, John List disappears after murdering his mother, wife and three children; he eludes the law for years until an age-scaled sculpture of the suspect and a true-crime TV program helps lead to his arrest in 1989.
When a woman goes missing from her home, police focus on her husband when an airline luggage tag and luminol point to an affair and murder; footage from a TV crew and Coast Guard photographs lead investigators to the suspect's missing boat.
Handwriting and simple doodles complicate a car-bomb case and an alleged self-defense shooting in a peaceful British farming village as police uncover a husband's plot to kill his wife for insurance money.
Investigators reopen a case from 1984 involving the rape of a young Virginia woman when DNA testing refutes her identification of the rapist and calls everything into question, leading to the accused person's exoneration.
A 2-year-old boy's brain seizures and breathing problems baffle doctors until they learn the mother exhibits signs of Munchausen syndrome by proxy, a rare condition that led her to physically abuse her son and contributed to her daughter's death.
A routine missing persons report leads Texas police to discover a deadly love triangle; evidence found in a suspect's home matches the murder scene and leads to the indictment of the victim's girlfriend and her lover.
In Lorton, Va., police attempt to determine who abducted 5-year-old Melissa Brannen after she disappears from a Christmas party, but cannot be certain until they match hair from a rabbit-fur jacket Brannen wore that day.
When a Pennsylvania man checks into a hospital for leg pain and later dies of thallium poisoning, police investigate his wife and find her in the process of collecting an insurance payment for her previous husband's death.
A cunning serial rapist who leaves no decisive evidence forces investigators to rely on geographical profiling in their search for an identity; DNA from a cigarette butt may provide the final piece of evidence needed to catch the suspect.
A mother and her two young daughters are found brutally murdered and sexually violated; the crime scene has no shortage of evidence, but investigators cannot find a conclusive link to their prime suspect.
A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.
When a young woman goes missing, the police investigation reveals that she led a double life -- student by day, call girl by night -- but when her body is discovered, even more strange truths are uncovered.
Investigators look into the shooting death of Russ Stager, a popular gym teacher, and discover that his death was not an accident; a message the victim recorded before his death reveals a story of greed.
A money launderer is found dead in the ocean and the only obvious clues to his identity are a Rolex watch and a tattoo; the anchor with which he is weighed down proves most helpful in solving the crime.
The 1992 hit-and-run death of 6-year-old Nicole Rae Walker leads to a groundbreaking trial as experts submit a video reconstruction of the incident, implicating a drunk driver and demonstrating the viability of video testimony.
When 4-year-old April Renee Tucker is found dead in her backyard, her parents tell the police that neighborhood dogs attacked and killed her, but the injuries on her body don't match their account of what happened.
When a man dies unexpectedly in the office of a noted California doctor, police begin what they think will be a routine investigation, but discoveries of false identities and insurance fraud raise questions about the doctor's role.
A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.
When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.
The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.
In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.
When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can; identification of a highly toxic metal in the victim's blood leads to his poisoner.
When young prostitute's body turns up in an Ohio waterway, authorities have one tiny clue which could point to her killer, but face huge challenges due to her policemen clients and DNA evidence being washed away.
A trash collector finds a severed human leg in a trash bin but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.
The body of a young California co-ed under an isolated interstate ramp sets off an investigation; San Diego police have no idea who would want her dead, but they discover a tiny, unique fiber on the victim's clothing.
Suicide notes and a pistol in hand lead police to suspect that a mother of two young children appeared to had killed herself, but when investigators learned of a house fire she was in three years earlier, they reinvestigate.
Security guard who disappeared from his post was found a year later in a remote camp site; a decade later, a phone call and a paint smear on his boot helped scientists determine what happened during his final moments.
A Naval officer who threatened to go public with tales of on-the-job sexual harassment and assault is brutally murdered, but when investigators find the allegations could be part of an elaborate scheme for money, they turn to forensic science.
A few drops of blood are the only clues a man's female killer leaves behind, but years later and hundreds of miles away investigators hear an intriguing story about an exotic dancer who got away with murder.
A shooting victim mutters the name of her apparent assailant before dying, but fingerprint comparisons, handwriting analysis, ballistics and DNA testing show someone else close to home is the true killer.
When friends see a woman in the back of a car flailing her arms and screaming, they assume she is having fun, but when they later come upon a jacket and a pool of blood, they realize they witnessed an abduction in progress.
Unsettling evidence is found in the rubble from a fire in a Seattle woman's apartment that is soon followed by another blaze just 100 feet from the first, with clues indicating a serial killer is at work.
The search for a missing exotic dancer led police to an isolated 75-acre site where someone had been shot and cremated, thus destroying all evidence... almost; piece of a foot provided enough DNA for a genetic profile and positive ID.
An Ohio woman and her two daughters go missing while vacationing in Florida; their corpeses are found floating in Tampa Bay with a hand-written note by one of the victims; putting it on five billboards helps them find the killer.