When Jane Doe is found naked in Times Square with her memory erased and body covered in fresh tattoos, Agent Kurt Weller and his FBI team work to solve the mystery, decoding the inked clues on Jane's body and searching for Jane's true identity.
When an op goes badly, the team must deal with a proverbial monster in their house before it can take them down one by one; Director Weitz is forced into a tense game of psychological chess as Madeline Burke attempts to assess his loyalty.
In order to stop a terrorist group from procuring a deadly chemical weapon, the team must remember key details from their first days at the FBI; Weller worries after he gets scary news about the health of his daughter.
When Jane is shot and Weller is kidnapped, the team must fight to save both of their lives while maintaining the secrecy of their hidden base; Weller is haunted by some dark ghosts from Blindspot's past.
When Ice Cream, the Icelandic fixer, returns to collect his debt, the team is forced into a life-and-death race around the world to solve a series of puzzles and recover the infamous stolen Gardner paintings.
To stop Madeline from shipping two planes full of ZIP to the U.S., the team splits up into a high-stakes undercover mission and intercepts Madeline's son; Madeline interrogates an old ally to get information on Kurt and the team.
The team scrambles to get ahead of Madeline and Ivy as they close in on the bunker's location, but someone on the inside is feeding Madeline information; as her plan takes shape, the team may be forced to take desperate measures.
With the surviving members of the team captured and held in FBI custody, Madeline and Ivy are in the final stages of their plan, but a few unlikely allies come out from the woodwork trying to stop her before it's too late.